James Leiper Selected Research

dimethylargininase

10/2020	Inhibition of Dimethylarginine Dimethylaminohydrolase 1 Improves the Outcome of Sepsis in Pregnant Mice.
12/2018	Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity.
1/2016	Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis.
6/2015	Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis.
11/2012	Genetic and pharmacological inhibition of dimethylarginine dimethylaminohydrolase 1 is protective in endotoxic shock.
6/2011	The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis.
8/2003	Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase.

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James Leiper Research Topics

Disease

6	Hypertension (High Blood Pressure) 01/2021 - 08/2003
6	Cardiovascular Diseases (Cardiovascular Disease) 09/2020 - 01/2010
4	Sepsis (Septicemia) 10/2020 - 06/2014
2	Septic Shock (Toxic Shock Syndrome) 10/2020 - 12/2018
2	Hypoxia (Hypoxemia) 08/2014 - 01/2008
2	Pulmonary Arterial Hypertension 08/2014 - 03/2011
2	Vascular Diseases (Vascular Disease) 09/2013 - 02/2008
1	Infectious Pregnancy Complications 10/2020
1	Obesity 09/2020
1	Hypertriglyceridemia 09/2020
1	Infections 01/2020
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2016
1	Stroke (Strokes) 10/2016
1	Pathologic Neovascularization 01/2016
1	Eye Diseases (Eye Disease) 01/2016
1	Ischemia 01/2016
1	Thrombosis (Thrombus) 02/2015
1	Atherosclerosis 02/2015
1	Pulmonary Hypertension 08/2014
1	Friedreich Ataxia (Friedreich's Ataxia) 08/2014
1	Nausea 08/2014
1	Ataxia (Dyssynergia) 08/2014
1	Familial Primary Pulmonary Hypertension 09/2013
1	Gastroesophageal Reflux (GERD) 08/2013
1	Shock 11/2012
1	Endotoxemia 11/2012
1	Idiopathic Pulmonary Fibrosis 06/2011
1	Fibrosis (Cirrhosis) 06/2011
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 06/2011
1	Vascular Remodeling 03/2011
1	Cardiomegaly (Heart Hypertrophy) 03/2011
1	Portal Hypertension 01/2007
1	Alcoholic Hepatitis 01/2007
1	Kidney Diseases (Kidney Disease) 08/2005
1	Chronic Kidney Failure (Chronic Renal Failure) 08/2003
1	Heart Failure 08/2003

Drug/Important Bio-Agent (IBA)

9	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 10/2020 - 08/2003
8	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2020 - 08/2003
7	dimethylargininaseIBA 10/2020 - 08/2003
5	Nitric Oxide Synthase (NO Synthase)IBA 10/2020 - 08/2003
3	LipopolysaccharidesIBA 01/2020 - 11/2012
3	dimethylarginineIBA 01/2016 - 01/2007
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2007
2	Biomarkers (Surrogate Marker)IBA 12/2018 - 01/2007
2	Oxygen (Dioxygen)IBA 01/2016 - 01/2008
1	SaltsIBA 01/2021
1	ElectrolytesIBA 01/2021
1	UromodulinIBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 10/2020
1	Imipenem FDA Link 10/2020
1	Progesterone FDA LinkGeneric 01/2020
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 12/2018
1	Vasopressins (Vasopressin)IBA 12/2018
1	2-tert-butylhydroquinone (tert-butylhydroquinone)IBA 01/2018
1	HomoarginineIBA 10/2016
1	omega-N-Methylarginine (NG Monomethyl L Arginine)IBA 01/2016
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2016
1	Retinaldehyde (Retinal)IBA 01/2016
1	Messenger RNA (mRNA)IBA 08/2014
1	Niacinamide (Nicotinamide)FDA LinkGeneric 08/2014
1	FrataxinIBA 08/2014
1	ChromatinIBA 08/2014
1	NitratesIBA 06/2014
1	CatecholaminesIBA 06/2014
1	NitritesIBA 06/2014
1	Connexin 43 (Connexin43)IBA 09/2013
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 08/2013
1	Proton Pump InhibitorsIBA 08/2013
1	EnzymesIBA 06/2012
1	Bleomycin (Blenoxane)FDA LinkGeneric 06/2011
1	indium-bleomycinIBA 06/2011
1	CollagenIBA 06/2011
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 06/2011
1	MonocrotalineIBA 03/2011
1	tolafentrineIBA 03/2011
1	CholesterolIBA 01/2010
1	rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA 01/2008
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2008
1	HydrolasesIBA 01/2007
1	symmetric dimethylarginineIBA 01/2007

Therapy/Procedure

2	Punctures 10/2020 - 01/2019
2	Ligation 10/2020 - 01/2019
2	Therapeutics 12/2018 - 06/2014
1	Drug Tapering 08/2014
1	Resuscitation 06/2014